Dr David Klyne
NHMRC Emerging Leadership Fellow
School of Health and Rehabilitation Sciences
Affiliate Senior Research Fellow of School of Biomedical Sciences
School of Biomedical Sciences
Affiliate of Centre for Innovation in Pain and Health Research (CIPHeR)
Centre for Innovation in Pain and Health Research
+61 7 336 54569
Researcher biography
David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc) is a NHMRC Emerging Leadership Fellow and Fulbright Scholar within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. There he leads an international team that probe the bio-psycho-social mechanisms that underlie physiological and pathological pain. His niche is in understanding the neuro-immune pathways involved and how they can be targeted with interventions using a blend of basic and clinical sciences and his skills and knowledge gained through his four degrees – neuro-immunology (PhD), molecular biology (Master), physiotherapy (Doctorate) and applied sciences (Bachelor).
David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also one of ten Australian scientists to attend the Lindau Nobel Laureate Meeting in 2019 and again in 2023, and has received more than $100K in research prize money and $17.5M in research funding.
Publications
Book Chapter
Farrell, Scott F., deZoete, Rutger M.J., Klyne, David M., Schmid, Annina B., Polli, Andrea, Nijs, Jo and Sterling, Michele (2024). Biological Contributors to Musculoskeletal Pain and Disability. Grieve's Modern Musculoskeletal Physiotherapy. (pp. 22-35) edited by Deborah Falla, Jeremy Lewis, Christopher McCarthy, Chad E. Cook and Michele Sterling. London, United Kingdom: Elsevier.
Journal Articles
Klyne, David M., Smith, Simon S. and Hall, Michelle (2024). Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? . Sleep, 47 (10) zsae177. doi: 10.1093/sleep/zsae177
Vygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M. and Han, Felicity Y. (2024). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain 104689, 104689. doi: 10.1016/j.jpain.2024.104689
Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M., van Dieën, Jaap H., Cholewicki, Jacek and Hodges, Paul W. (2024). Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability. European Spine Journal, 33 (6), 2380-2394. doi: 10.1007/s00586-024-08205-w
Barbe, Mary F., Chen, Frank Liu, Loomis, Regina H., Harris, Michele Y., Kim, Brandon M., Xie, Kevin, Hilliard, Brendan A., McGonagle, Elizabeth R., Bailey, Taylor D., Gares, Ryan P., Van Der Bas, Megan, Kalicharan, Betsy A., Holt-Bright, Lewis, Stone, Laura S., Hodges, Paul W. and Klyne, David M. (2024). Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Frontiers in Pain Research, 5 1394017, 1-23. doi: 10.3389/fpain.2024.1394017
Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2024). Coordination of hip and spine in individuals with acute low back pain during unstable sitting. The Spine Journal, 24 (5), 768-782. doi: 10.1016/j.spinee.2023.12.001
Klyne, David M and Hall, Michelle (2024). Is sleep the new treatment for pain? Two issues need resolving before deciding. SLEEP, 47 (6) zsae089. doi: 10.1093/sleep/zsae089
Klyne, David M., Hilliard, Brendan A., Harris, Michele Y., Amin, Mamta, Hall, Michelle, Besomi, Manuela, Mustafa, Sanam, Farrell, Scott F., Rawashdeh, Oliver, Han, Felicity Y., Hodges, Paul W., Frara, Nagat and Barbe, Mary F. (2024). Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury. Brain, Behavior, and Immunity - Health, 35 100714. doi: 10.1016/j.bbih.2023.100714
Alshehri, Mansour Abdullah, Alzahrani, Hosam, van den Hoorn, Wolbert, Klyne, David M., Vette, Albert H., Hendershot, Brad D., Roberts, Brad W. R., Larivière, Christian, Barbado, David, Vera-Garcia, Francisco J., van Dieen, Jaap H., Cholewicki, Jacek, Nussbaum, Maury A., Madigan, Michael L., Reeves, Norman Peter, Silfies, Sheri P., Brown, Stephen H. M. and Hodges, Paul W. (2024). Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis. PLoS One, 19 (1) e0296968, 1-42. doi: 10.1371/journal.pone.0296968
Pang, Huiwen, Chen, Shihui, Klyne, David M., Harrich, David, Ding, Wenyuan, Yang, Sidong and Han, Felicity Y. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research, 11 (1) 42, 42. doi: 10.1038/s41413-023-00280-x
Hall, Michelle, Dobson, Fiona, Klyne, David Murray, Zheng, Carmen Jiamin, Lima, Yuri Lopes and Egorova-Brumley, Natalia (2023). Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis. Scientific Reports, 13 (1) 12442. doi: 10.1038/s41598-023-39245-9
Plinsinga, Melanie Louise, Vuvan, Viana, Maclachlan, Liam, Klyne, David, Graven-Nielsen, Thomas, Vicenzino, Bill, Hodges, Paul and Bjarke Vaegter, Henrik (2023). Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain. Pain, 164 (7), 1593-1599. doi: 10.1097/j.pain.0000000000002864
Farrell, Scott F., Sterling, Michele, Klyne, David M., Mustafa, Sanam, Campos, Adrián I., Kho, Pik-Fang, Lundberg, Mischa, Rentería, Miguel E., Ngo, Trung Thanh and Cuéllar-Partida, Gabriel (2023). Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain. European Spine Journal, 32 (6), 2078-2085. doi: 10.1007/s00586-023-07711-7
Lima, Yuri Lopes, Lee, Hopin, Klyne, David M., Dobson, Fiona L., Hinman, Rana S., Bennell, Kim L. and Hall, Michelle (2023). How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies. Arthritis Care and Research, 75 (3), 467-481. doi: 10.1002/acr.24983
Hall, Michelle, Allison, Kim, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, Knox, Gabrielle, Plinsinga, Melanie, Klyne, David M., McManus, Fiona, Lamb, Karen E., Da Costa, Ricardo, Murphy, Nicholas J. and Dobson, Fiona L. (2022). Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial. BMC Musculoskeletal Disorders, 23 (1) 361. doi: 10.1186/s12891-022-05282-0
van den Hoorn, Wolbert, Meroni, Roberto, Klyne, David M., Alshehri, Mansour Abdullah and Hodges, Paul W. (2022). Balance control in unstable sitting in individuals with an acute episode of low back pain. Gait and Posture, 95, 15-21. doi: 10.1016/j.gaitpost.2022.03.014
Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLoS One, 17 (5) e0268381, 1-14. doi: 10.1371/journal.pone.0268381
Klyne, David Murray, Hall, Leanne Marie, Nicholas, Michael K. and Hodges, Paul William (2022). Risk factors for low back pain outcome: Does it matter when they are measured?. European Journal of Pain, 26 (4), 835-854. doi: 10.1002/ejp.1911
Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2022). Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain. The Spine Journal, 22 (2), 214-225. doi: 10.1016/j.spinee.2021.09.006
Klyne, David M., Barbe, Mary F., James, Greg and Hodges, Paul W. (2021). Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?. International Journal of Molecular Sciences, 22 (14) 7299, 1-21. doi: 10.3390/ijms22147299
Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2021). Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis. Journal of Neurophysiology, 125 (5), 1814-1824. doi: 10.1152/jn.00555.2020
Klyne, David M., van den Hoorn, Wolbert, Barbe, Mary F., Cholewicki, Jacek, M. Hall, Leanne, Khan, Asaduzzaman, Meroni, Roberto, Moseley, G. Lorimer, Nicholas, Michael, O’Sullivan, Lee, Park, Rachel, Russell, Glen, Sterling, Michele and Hodges, Paul W. (2020). Cohort profile: why do people keep hurting their back?. BMC Research Notes, 13 (1) 538, 538. doi: 10.1186/s13104-020-05356-z
van den Hoorn, Wolbert, Cholewicki, Jacek, Coppieters, Michel W., Klyne, David M. and Hodges, Paul W. (2020). Trunk stiffness decreases and trunk damping increases with experimental low back pain. Journal of Biomechanics, 112 110053, 110053. doi: 10.1016/j.jbiomech.2020.110053
Barbe, Mary F., Hilliard, Brendan A., Amin, Mamta, Harris, Michele Y., Hobson, Lucas J., Cruz, Geneva E., Dorotan, Jocelynne T., Paul, Ryan W., Klyne, David M. and Popoff, Steven N. (2020). Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy. Journal of Orthopaedic Research, 38 (11) jor.24709, 2396-2408. doi: 10.1002/jor.24709
Klyne, David M. and Hodges, Paul W. (2020). Circulating adipokines in predicting the transition from acute to persistent low back pain. Pain Medicine, 21 (11), 2975-2985. doi: 10.1093/pm/pnaa052
Smith, Tianqi Tenchi Gao, Barr-Gillespie, Ann E, Klyne, David M, Harris, Michelle Y, Amin, Mamta, Paul, Ryan W, Cruz, Geneva E, Zhao, Huaqing, Gallagher, Sean and Barbe, Mary F (2020). Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders. BMC Musculoskeletal Disorders, 21 (1) 57, 57. doi: 10.1186/s12891-020-3085-z
Klyne, David M. and Hodges, Paul W. (2019). Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al. Spine Journal, 19 (11), 1899-1900. doi: 10.1016/j.spinee.2019.06.011
Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2019). Are signs of central sensitisation in acute low back pain a precursor to poor outcome?. The Journal of Pain, 20 (8), 994-1009. doi: 10.1016/j.jpain.2019.03.001
James, G., Klyne, D. M., Millecamps, M., Stone, L. S. and Hodges, P. W. (2019). ISSLS Prize in Basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. European Spine Journal, 28 (5), 893-904. doi: 10.1007/s00586-019-05902-9
Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2018). Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors. The Journal of Pain, 19 (8), 942.e1-942.e18. doi: 10.1016/j.jpain.2018.02.017
Klyne, David M., Barbe, Mary F, van den Hoorn, Wolbert and Hodges, Paul W. (2018). ISSLS Prize in clinical science 2018: Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly. European Spine Journal, 27 (4), 763-777. doi: 10.1007/s00586-018-5490-7
Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2017). Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain, Behavior, and Immunity, 60, 84-92. doi: 10.1016/j.bbi.2016.10.003
Klyne, David M., Schmid, Annina B., Moseley, G. Lorimer, Sterling, Michele and Hodges Paul W. (2015). Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation. Journal of Pain, 16 (2), 176-185. doi: 10.1016/j.jpain.2014.11.005
Klyne, David M., Keays, Susan L., Bullock-Saxton, Joanne E. and Newcombe, Peter A. (2012). The effect of anterior cruciate ligament rupture on the timing and amplitude of gastrocnemius muscle activation: A study of alterations in EMG measures and their relationship to knee joint stability. Journal of Electromyography and Kinesiology, 22 (3), 446-455. doi: 10.1016/j.jelekin.2012.01.013
Conference Papers
Hall, Michelle, Allison, Kim, Knox, Gabrielle, Hinman, Rana S., Bennell, Kim, Spiers, Libby, Plinsinga, Melanie, Klyne, David, McManus, Fiona, De Silva, Anurika, Da Costa, Ricardo, Murphy, Nicholas and Dobson, Fiona (2024). The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.03.098
Hall, M., Dobson, F., Klyne, D., Zheng, C., Lima, Y. and Egorova-Brumley, N. (2023). Neurobiology of Osteoarthritis - A Systematic Review and Activation Likelihood Estimation Meta-analysis. World Congress of Osteoarthritis Research Society International (OARSI), Denver, CO United States, 17-20 March 2023. London, United Kingdom: Elsevier.
Hall, M., Dobson, F., Klyne, D., Zheng, C., Lima, Y. and Egorova-Brumley, N. (2023). Neurobiology Of Osteoarthritis - A Systematic Review And Activation Likelihood Estimation Meta-Analysis. 2023 OARSI World Congress on Osteoarthritis, Denver, CO United States, 17-20 March 2023. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2023.01.431
Klyne, D.M., Hilliard, B., Harris, M., Amin, M., Testa, C., Hobson, L., Cruz, G., Hodges, P.W. and Barbe, M.F. (2021). Uncovering the role of sleep and exercise in the transition from acute to persistent pain. Psychoneuroimmunology Research Society's 27th Annual Meeting, Online, 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.bbi.2021.08.099
Klyne, D. M. (2019). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly. PsychoNeuroImmunology Research Society's 25th Annual Scientific Meeting, Miami Beach, FL, United States, 6-9 June 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.bbi.2018.11.244
Klyne, David, Barbe, Mary, Van Den Hoorn, Wolbert and Hodges, Paul (2018). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: a potential factor in tissue effects in low back pain. 5th International Fascia Research Congress, Berlin, Germany, 14-15 November 2018. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jbmt.2018.09.056
Creative Work
McPhee, Megan, Klyne, David and Graven-Nielsen, Thomas (2021). Environmental contributors to back pain. Washington, DC, USA: International Association for the Study of Pain.
Data Collection
Alshehri, Mansour Abdullah , van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2021). Supplemental Data for "Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper. The University of Queensland. (Dataset) doi: 10.14264/c3f49b3
Thesis
Klyne, David Murray (2018). Biological factors in the transition from acute to persistent low back pain. PhD Thesis, School of Health and Rehabilitation Sciences, The University of Queensland. doi: 10.14264/uql.2018.468